Author Profile

Dr. Michael Stiff, PhD shapes the future of medicine at the intersection of technology and human empathy. He navigates the high-stakes environment of emergency departments, translating chaotic clinical symptoms into precise medical data. His eyes scan both glowing monitors and the anxious faces of patients, finding the human story hidden inside complex diagnostics. His writing reflects this dual world, balancing sharp scientific accuracy with a deep understanding of patient care. When he steps away from the hospital, he restores vintage fountain pens and sketches architectural geometry. He balances his high-tech career by living off-grid in a solarpowered cabin outside Denver, Colorado. He has done research in neuropharmacology, specifically the mechanisms of epilepsy, anticonvulsant drugs, and the neurochemical alterations associated with epileptogenesis; Evaluating how standard and experimental anti-epileptic drugs modulate cortical excitability and GABAergic systems; Investigating the roles of trace metals-particularly zinc, copper, and manganese-in the development of seizures and brain excitability; and researching the behavior of excitatory amino acids (like glutamate) and inhibitory pathways in central nervous system disorders.

About The Book

Clinical pharmacology is the scientific study of drugs in humans. It bridges basic pharmacology and clinical practice by focusing on the optimal, safe, and personalized use of medications. It serves as a core discipline in both medical patient care and new drug development. The book ‘Clinical Applications of Modern Pharmacology’ designed to be used during a single semester, the book focuses on the clinical application of drugs within a context of the major principles of pharmacology. It is meant to serve students in medicine, osteopathy, dentistry, pharmacy, and advanced nursing, as well as undergraduate students. The book is expertly organized to translate scientific concepts into real-world pharmacotherapeutics. Rather than just listing drug mechanisms, it explores how pharmacological principles dictate patient treatment. Key areas covered include: Detailed explanations of how the body handles drugs (absorption, distribution, metabolism, excretion) and how drugs act at cellular and molecular targets; Categorized sections on drugs affecting major bodily systems (e.g., central nervous system, cardiovascular, respiratory, and endocrine); Emphasizes therapeutic rationales, drug interactions, and potential toxicities to ensure safe and cautious prescribing.

Table of Contents

Preface
1.
GENERAL PHARMACOLOGY.............................................................................1
1.1 Rational Drug Use in Clinical Practice
1.2 Clinical Pharmacokinetics
1.3 Posology (Dose Calculations)
1.4 Chronotherapeutics
1.5 Dosing in Pediatric Group
1.6 Geriatric Pharmacology
1.7 Drug Use in Pregnancy
1.8 Drug Use in Lactation
1.9 Drug Interactions
2.
CENTRAL NERVOUS SYSTEM...........................................................................37
2.1 Treatment of Alcohol Use Disorder
2.2 Treatment of Epilepsy
2.3 Treatment of Parkinsonism
2.4 Treatment of Psychotic and Mood Disorders
2.5 Treatment of Acute and Chronic Pain and Treatment of Migraine
2.6 Treatment of Alzheimer’s Disease
3.
CARDIOVASCULAR SYSTEM.............................................................................92
3.1 Management of Hypertension
3.2 Treatment of Hyperlipidemia
3.3 Treatment of Angina and Myocardial Infarction
3.4 Treatment of Congestive Heart Failure
3.5 Treatment of Shock
4.
BLOOD............................................................................................................123
4.1 Hemopoietic Agents and Treatment of Anemia
4.2 Treatment of Bleeding Disorders
4.3 Treatment of Thromboembolic Disorders
5.
KIDNEY AND URINARY TRACT.......................................................................143
5.1 Infections of Kidney and Urinary Tract
6.
JOINT DISORDERS..........................................................................................158
6.1 Treatment of Rheumatoid Arthritis and Gout
7.
RESPIRATORY SYSTEM...................................................................................166
7.1 Treatment of Respiratory Diseases
7.2 Pulmonary Function Tests
8.
GIT, LIVER, PANCREAS...................................................................................206
8.1 Treatment of Diarrhea, Constipation and Vomiting
8.2 Treatment of Peptic Ulcer
8.3 Treatment of Liver, Intestine, and Pancreatic Diseases
9.
ENDOCRINE SYSTEM......................................................................................226
9.1 Treatment of Diabetes Mellitus
9.2 Treatment of Thyroid Disorders
9.3 Treatment of Gynecological Disorders and Obstetric Complications
9.4 Treatment with Androgens in Various Clinical Disorders
9.5 Treatment of Adrenal Hormones Disorders
10.
TREATMENT OF INFECTIOUS DISEASES........................................................259
10.1 Treatment of Malaria
10.2 Treatment of Tuberculosis
10.3 Treatment of Viral Illness
10.4 Treatment of AIDS (Acquired Immunodeficiency Syndrome)
10.5 Use of Antimicrobials
10.6 Treatment of Fungal Diseases
10.7 Treatment of Amoebiasis and Other Protozoal Infections
10.8 Anthelmintic Drugs
10.9 Treatment of Leprosy
10.10 Treatment of Sexually Transmitted Diseases
Bibliography....................................................................................................307
Index...............................................................................................................317